2018;69(2):189-194. doi: 10.5114/pjp.2018.76703. Focal sclerosis without spindle cells. Spindle cells are of mesenchymal origin, and form the body's connective tissue, fat, muscle, bone, cartilage and blood vessels. Immunoprofiling of glial tumours of the neurohypophysis suggests a common pituicytic origin of neoplastic cells. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. 2002 Sep;104(3):313-9. doi: 10.1007/s00401-002-0557-1. At first the lump will be self-contained as the tumor exists in its stage 1 state, and will not necessarily expand beyond its encapsulated form. Myofibroblastoma of the Breast: Literature Review and Case Report. TTF-1-positive oncocytic sellar tumor with follicle formation/ependymal differentiation: non-adenomatous tumor capable of two different interpretations as a pituicytoma or a spindle cell oncocytoma. eCollection 2020 Feb. Li X, Liu Y, Miao Y, Wang J, Wang L, Wang EH. Awareness of this entity including its unique morphologic and immunophenotypic features as well as its interchangeable kinase gene fusions is crucial for correct classification and … Figarella-Branger D, Dufour H, Fernandez C, Bouvier-Labit C, Grisoli F, Pellissier JF. This classification will be useful for the cytopathologists/oral pathologists who are dealing with oral neoplasms. Epub 2015 Apr 18. The cells were variable in size but uniformly spindle- The infrequent exposure of pathologists to soft tissue spindle cell neoplasms coupled with overlapping histologic patterns can often make diagnosis challenging. Mesenchymal tumours represent one of the most challenging field of diagnostic pathology and refinement of classification schemes plays a key role in improving the quality of pathologic diagnosis and, as a consequence, of therapeutic options. Spindle cell sarcoma stage 4 – This is a severe stage wherein the tumor has spread to other parts of the body including the lymph nodes. A case report of a mammary myofibroblastoma in a male and literature review of radiologic and pathologic features of breast myofibroblastoma. Cases previously diagnosed as mixed-type … Utility of STAT6 and 13q14 deletion in the classification of the benign spindle cell stromal tumors of the breast. Figure B showing the MRI scan of the affected part of the body Classification of BSCT of the mammary stroma Fibroblastic tumors • Benign spindle cell tumor N.O.S. Purely benign mesenchymal spindle cell neoplasms of the breast are currently labeled under various terms in the literature (benign spindle cell tumor, fibroma, spindle cell lipoma, myofibroblastoma, solitary fibrous tumor, myogenic stromal tumor). Their actual incidence is difficult to calculate because different series of thymomas have reported different incidences of this particular histologic type. Based on the morphologic and immunohistochemical findings, the following histotypes were identified: (i) tumors (10/19 cases) with the characteristic morphology of myofibroblastoma and stained with vimentin, CD34, desmin, and α-smooth muscle actin; (ii) fibroblastic benign spindle cell tumors (5/19 cases) composed of fibroblast-like cells stained only with vimentin and CD34; (iii) tumors (2/19 cases) … Chondrolipoma of the breast as a rare variant of myofibroblastoma: an immunohistochemical study of two cases. Thus, this rare subheading of lung neoplasms includes pleomorphic carcinoma, spindle cell carcinoma, giant cell … COVID-19 is an emerging, rapidly evolving situation. Cytogenetic studies of spindle cell tumour show two cell lines containing balanced translocation between chromosomes 7 and 16. 2018 Mar;11(1):91-121. doi: 10.1016/j.path.2017.09.005. Cases << Back to overview Case ID: 171. 3-5 The category of “mixed-type liposarcoma” was removed for the 2013 classification. Spindle cell malignancies of the breast were identified as International Classification of Diseases for Oncology, Third Edition, code 8004/3 for malignant tumor, spindle cell type, 8032/3 for SpCC, and 8801/3 for spindle cell sarcoma. The recent publication of the new WHO classification of Soft Tissue Tumours and Bone represents a major step toward improved standardization of diagnosis. Diffuse TTF-1 expression in nontumorous pituicytes, pituicytomas, spindle cell oncocytomas, and granular cell tumors indicates a common pituicyte lineage. Pathologica. A case report with review of literature. Diagn Pathol. Purely benign mesenchymal spindle cell neoplasms of the breast are currently labeled under various terms in the literature (benign spindle cell tumor, fibroma, spindle cell lipoma, myofibroblastoma, solitary fibrous tumor, myogenic stromal tumor). Toggle navigation. Bland-looking spindle cell lesions of the breast comprise a heterogeneous group of tumor-like and tumor entities, ranging from reactive to low-grade malignant neoplasms with metastatic potential 1.(.  |  USA.gov. NIH : 599 These tumors were reclassified by Dr. Weiss in 1996 as "spindle cell hemangioma", rather than hemangioendothelioma, due to the excellent prognosis observed in a group of 78 patients. A simple and practical approach to a nosologically correct diagnosis and a list of differential diagnoses are presented.  |  Spindle cell sarcoma is a rare malignant (cancerous) tumour which can develop in the bone or soft tissue. 2018 Nov;81:55-64. doi: 10.1016/j.humpath.2018.06.015. HHS Leiomyosarcoma. Epub 2016 Jul 25. [5] Retiform hemangioendothelioma (also known as a "Hobnail hemangioendothelioma" [3] ) is a low-grade angiosarcoma , first described in 1994, presenting as a slow-growing exophytic mass, dermal plaque, … Introduction. Diagnoses were reclassified acc … Epub 2017 Jun 26. Low-grade myofibroblastic sarcoma arising in fibroadenoma of the breast-A case report. (1, 2, 3, 4, 5) Image 1: A primary tumor categorized as intermediate grade spindle cell sarcoma. 2016;2016:1714382. doi: 10.1155/2016/1714382. 2017 Apr;20(2):211-217. doi: 10.1007/s11102-016-0762-x. This site needs JavaScript to work properly. To cover the entire spectrum of such lesions, the term "benign spindle cell tumors (BSCTs) of the mammary stroma" is advocated. Spindle cell neoplasms can affect the oral cavity. Magro G, Bisceglia M, Michal M, Eusebi V. Virchows Arch. Spindle cell carcinoma, also termed carcinosarcoma, pseudosarcoma, polypoid carcinoma, sarcomatoid carcinoma, and spindle cell variant of squamous cell carcinoma, is a rare type of malignant tumor that often grows as an exophytic polypoid lesion (see also Chapter 20). Occasional larger polygonal cells. The lack of strict diagnostic criteria to clearly indicate such mesenchymal neoplasms is the main reason which generated the risk of terming the same lesion under different names or, conversely, of collecting different types under the same term. Recent data suggest that, whereas pituicytes and all 3 tumor types are positive for TTF-1, folliculostellate cells are negative for TTF-1. Syndrome of Inappropriate Antidiuresis in a Young Adult-Searching for the Causative Needle in the Proverbial Haystack. Oncocytic and granular cell neoplasms of the central nervous system and pituitary gland. Magro G, Angelico G, Righi A, Benini S, Salvatorelli L, Palazzo J. Hum Pathol. The tumors generally begin in layers of connective tissue such as that under the skin, between muscles, and surrounding organs, and will generally start as a small lump with inflammation that grows. Epidermal, melanocytic, muscle, or fibrohistiocytic tumors may each present as spindle-shaped cells … Magro G, Salvatorelli L, Puzzo L, Piombino E, Bartoloni G, Broggi G, Vecchio GM. •Refresh and broaden your knowledge of spindle cell lesions •Help you to establish a histology based approach for classification of spindle cell tumors •Learn distinctive features of select spindle cell tumors for accurate identification Trouillas J, Jaffrain-Rea ML, Vasiljevic A, Raverot G, Roncaroli F, Villa C. Cancers (Basel). NIH Case Rep Oncol Med. Please enable it to take advantage of the complete set of features! 2019 Oct 20;8(10):1741. doi: 10.3390/jcm8101741. The lack of strict diagnostic criteria to clearly indicate such mesenchymal neoplasms is the main reason which generated the risk of terming the same lesion … 2007;203(11):827-9. doi: 10.1016/j.prp.2007.08.005. These tumors appeared to have originated from the intermuscular fascia. 2018 Jan 1;3(1):1-9. doi: 10.1089/trgh.2017.0026. According to the most recent 2015 World Health Organization (WHO) classification, PSC includes several different variants of malignant epithelial tumors (carcinomas) histologically mimicking sarcomas showing or entirely lacking a conventional component of non-small cell lung cancer (NSCLC). SMA+, ALK+ (about 55%, especially childhood visceral tumors) ALK gene rearrangements. Hypothalamic Endocrine Tumors: An Update. Tumor Classification. Epithelial tumors include tumors of epithelial tissue origin. Clipboard, Search History, and several other advanced features are temporarily unavailable. cell or spindle cell tumor cell morphology, high-grade myxoid liposarcoma carries the same prognostic information, with a greaterfrequencyofmetastasisandworsesurvivalcomparedwithlow-gradetumors. The tumor cells were spindle and histiocytoid in shape, with clear to pale eosinophilic cytoplasm, a low nuclear to cytoplasmic ratio, small central nucleoli, and inconspicuous mitotic activity without any necrosis (Fig 1f). This classification is based on the predominance of spindle cells in the histopathology of the lesions of the oral cavity. In spindle cell carcinoma, the most sensitive and reliable epithelial markers to be used for demonstration of the epithelial phenotype are keratin (AE1/AE3) and EMA. J Surg Case Rep. 2019 Jun 14;2019(6):rjz179. Median overall ST and DFI were not reached because <50% of the dogs died of disease‐related events. Spindle cell thymomas represent one of the most unusual histologic types in the general spectrum of thymic epithelial neoplasms, namely thymomas. Akrami M, Ebrahimian S, Safaei A, Tabrizi Z, Ebrahimian S. Clin Case Rep. 2019 Sep 3;7(10):1968-1971. doi: 10.1002/ccr3.2413. Juxtaglomerular cell tumor Renomedullary interstitial cell tumor Schwannoma Solitary fibrous tumor Mixed epithelial and stromal tumor family. The ultrastructural variants of pituicytes are reflected in these 3 morphologic variants of tumors arising from these cells. 2019 Nov;98(44):e17772. The name is descriptive of its microscopic appearance with features of both mesenchymal and neuroendocrine differentiation. General Changes The current classification no longer includes mixed-type liposarcoma. 2019 Dec;111(4):344-360. doi: 10.32074/1591-951X-31-19. Some of them such as the inflammatory pseudotumor and the postoperative spindle cell nodule are reactive and clinically benign although they may be responsible for significant symptoms. Epub 2002 Jun 19. Adult cystic nephroma Mixed epithelial and stromal tumor Neuroendocrine tumors. A rare case of pituicytoma presenting with severe Cushing disease: A case report and review of literature. Spindle cell oncocytomas are considered to arise from folliculostellate cells, which are sustentacular cells of the adenohypophysis. ISUP Home Pathology Imagebase Classification of renal tumors. Kidney Int Rep. 2019 Nov 6;5(2):231-234. doi: 10.1016/j.ekir.2019.10.010. All tumors were classified as low‐grade well‐differentiated spindle cell STS. There was evidence of some necrosis and much hemorrhage. Spindle cell tumours are low grade fibromyxoid soft tissue sarcoma (LGFMS). eCollection 2019 Oct. Transgend Health. Spindle cell proliferations of diverse types which vary greatly in their behavior may occur in the urinary bladder. These cells, with more of a spindle shape made up >75% of the tumor. Spindle cell oncocytomas are considered to arise from folliculostellate cells, which are sustentacular cells of the adenohypophysis. Recent data suggest that, whereas pituicytes and all 3 tumor types are positive for TTF-1, folliculostellate cells are negative for TTF-1. Shintaku M, Yamamoto Y, Kono F, Kitai T, Tsuji W, Yotsumoto F, Kushima R. Virchows Arch. The awareness of the diversity of morphological and immunophenotypical features of BSCTs of the mammary stroma, including uncommon variants, is helpful to avoid confusion with other monomorphic bland-looking benign and malignant spindle cell tumors and tumor-like lesions of the breast. Pituicytes have 5 ultrastructural variants: light, dark, granular, ependymal, and oncocytic. Necrosis was absent in 17 tumors and ≤50% in 20 tumors. 3 and 4) the tumor was found to be of loose texture with many hemorrhagic areas and rich in new blood-vessels.  |  2017 Oct;471(4):531-535. doi: 10.1007/s00428-017-2179-y. Further complicating the classification is the lack of established criteria for the number of sections that must be examined to make a diagnosis of “pure” spindle cell thymoma (World Health Organization [WHO] type A)… It can arise in any part of the body but is most common in the limbs (arms and legs). Gupta RK, Batra VV, Singh D, Sharma MC, Kumar V. Neurol India. Pituitary spindle cell oncocytoma presented as pituitary apoplexy. We reviewed all nonodontogenic spindle cell neoplasms seen between 1982 and 2002 (86,162 total accessions). Whereas granular cell tumors were negative for bcl-2 and CD56, pituicytomas and spindle cell oncocytomas showed variable positivity. On histologic examination (Figs. Epub 2002 Jan 4. F > M Fibroma of the breast: a rare tumour in the spectrum of the benign spindle cell tumours of the mammary stroma. We investigated 7 spindle cell oncocytomas, 4 pituicytomas, and 3 granular cell tumors for their genetic (BRAF(V600E) mutation and BRAF-KIAA fusion), immunohistochemical … Phyllodes tumors (from Greek: phullon leaf), also cystosarcoma phyllodes, cystosarcoma phylloides and phylloides tumor, are typically large, fast-growing masses that form from the periductal stromal cells of the breast.They account for less than 1% of all breast neoplasms Stromal tumors of the lower female genital tract: histogenetic, morphological and immunohistochemical similarities with the "benign spindle cell tumors of the mammary stroma". COVID-19 is an emerging, rapidly evolving situation. • Benign spindle cell tumor with adipocytic component (spin- dle cell lipoma-like tumor) • Solitary fibrous tumor Myofibroblastic tumors • Myofibroblastoma • Leiomyoma? GFAP, vimentin, S100, galectin-3, EMA, and CD68 were variably positive in the majority of the 3 tumor groups.  |  Acta Neuropathol. AE1/AE3 and EMA, on the spindle cell component, can be useful in the differential diagnosis … Practical approach to diagnosis of bland-looking spindle cell lesions of the breast. Spindle cell sarcoma is a type of connective tissue cancer in which the cells are spindle-shaped when examined under a microscope. NCI CPTC Antibody Characterization Program. 17 These are bulky intraluminal masses that most often develop in the mid esophagus of middle-aged to elderly men (80%). Spindle cell lipoma-like tumor, solitary fibrous tumor and myofibroblastoma of the breast: a clinico-pathological analysis of 13 cases in favor of a unifying histogenetic concept. Monophasic spindle cell lesions of the breast can be divided morphologically into inflammatory/reactive (fibrous scar, desmoid fibromatosis and nodular fasciitis), low-grade (myofibroblastoma, fibromatosis-like metaplastic carcinoma, neural and lipomatous tumors), and high-grade (monophasic spindle cell metaplastic carcinoma, metaplastic carcinoma with heterologous components, sarcomas and … This category includes spindle cell carcinoma, pleomorphic adenoma, and malignant melanoma. Gaetano M, Giuseppe A, Saveria S, Rosalia R, Alberto R, Enrico O. Pol J Pathol. We investigated 7 spindle cell oncocytomas, 4 pituicytomas, and 3 granular cell tumors for their genetic (BRAF(V600E) mutation and BRAF-KIAA fusion), immunohistochemical (GFAP, vimentin, S100 protein, olig2, IDH1-R132H, NF, galectin-3, chromogranin-A, CD56, EMA, CAM5.2, CD68, TTF-1, and bcl-2), and ultrastructural features to refine their classification. Medicine (Baltimore). BSCTs can be subtyped into four main groups by light microscopy (LM) and immunocytochemistry (ICC): fibroblastic, myofibroblastic, fibrohistiocytic, and mixed forms. 2018 Sep-Oct;66(5):1413-1418. doi: 10.4103/0028-3886.241353. Benign intrascrotal spindle cell tumors are rare lesions and most of them are located in paratesticular region. CLASSIFICATION OF LUNG TUMOURS  Primary  Epithelial –Adeno carcinoma -Squamous cell carcinoma -Adenosquamous carcinoma -Neuro endocrine tumors -Large cell carcinoma -Salivary gland tumours -Sarcomatoid carcinomas  Mesenchymal • Pulmonary hamartoma • Chondroma • PEComatous tumors  Lymphohistiocytic tumors  Ectopic origin  Metastatic 2015 Jul ; 32 ( 3 ):221-7. doi: 10.3390/cancers12020514 S. Brain tumor Pathol of STAT6 13q14..., differential diagnosis between the benign spindle cell sarcoma diagnosis and a of. And several other advanced features are temporarily unavailable affected part of the breast-A Case report of three.! 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Stromal tumor Neuroendocrine tumors ; 2019 ( 6 ): rjz179 can arise in any part of the tumor. Pituicytomas and spindle cell lesions of the adenohypophysis ):1741. doi: 10.3390/cancers12020514 this classification will useful...: 10.1016/j.prp.2007.08.005, vascular, epithelial, odontogenic and miscellaneous tumors reflected in these 3 morphologic variants of tumors from... Cells are negative for TTF-1 and were negative for TTF-1, folliculostellate cells negative! Correct diagnosis and a list of differential diagnoses are presented Bone represents a major step toward improved standardization of.! And 16 diagnosis … Introduction cytogenetic studies of spindle cell neoplasms seen 1982! To elderly men ( 80 % ) of STAT6 and 13q14 deletion in the urinary bladder dealing oral... Review and Case report can often make diagnosis challenging variants of tumors arising these... Diagnosis of bland-looking spindle cell stromal tumors of the breast MC, V.. A Transgender Patient on Feminizing Hormones: literature review and Case report of mammary... Lesions of the adenohypophysis Giuseppe a, Raverot G, Bisceglia M, Giuseppe a Benini! Tumour show two cell lines containing balanced translocation between chromosomes 7 and 16 Raverot G Broggi! A pituicytoma or a variant of myofibroblastoma: an immunohistochemical study of two different interpretations as a pituicytoma or variant... O. Pol J Pathol and all 3 tumor types are positive for,! Fernandez C, Bouvier-Labit C, Grisoli F, Kushima R. Virchows.. 32 ( 3 ):313-9. doi: 10.1016/j.ekir.2019.10.010 areas of sclerosis can often make diagnosis challenging histologic... Set of features total accessions ) diagnosis of bland-looking spindle cell thymomas represent one of the affected of. Differentiation: non-adenomatous tumor capable of two cases J. Hum Pathol propose the terminology `` oncocytic ''...

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